"Methods, Processes, and Tools for Collaboration -The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types.---Bryn Williams-Jones, Associate Research Fellow, Pfizer The pharmaceutical industry utilizes an extended network of ..."
Drug Efficacy, Safety, and Biologics Discovery(1st Edition) Emerging Technologies and Tools (Wiley Series on Technologies for the Pharmaceutical Industry) by SeanEkins, Jinghai J. Xu Hardcover, 424 Pages, Published 2009 by Wiley ISBN-13: 978-0-470-22555-4, ISBN: 0-470-22555-6
""Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools" covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery ..."
Computational Toxicology(1st Edition) Risk Assessment for Chemicals (Wiley Series on Technologies for the Pharmaceutical Industry) by SeanEkins Hardcover, 432 Pages, Published 2018 by Wiley ISBN-13: 978-1-119-28256-3, ISBN: 1-119-28256-X
"A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals.• Provides a perspective of what is currently achievable with computational toxicology and a view to future developments• Helps readers overcome questions of data sources, curation, treatment, and how ..."
"A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, includi ..."
"This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug ..."
"Pharmaceutical and Biomedical Portfolio Management in a Changing Global Environment explores some of the critical forces at work today in the complex endeavour of pharmaceutical and medical product development. Written by experienced professionals, and including real-world approaches and best practice examples, this new title addresses three key areas – small molecules, large molecules, and medical devices - and provides hard-to-find, ..."
The Agile Approach to Adaptive Research(1st Edition) Optimizing Efficiency in Clinical Development (Wiley Series on Technologies for the Pharmaceutical Industry) by Michael J. Rosenberg, SeanEkins Hardcover, 304 Pages, Published 2010 by Wiley ISBN-13: 978-0-470-24751-8, ISBN: 0-470-24751-7
"Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. Wi ..."
The Engines of Hippocrates(1st Edition) From the Dawn of Medicine to Medical and Pharmaceutical Informatics (Wiley Series on Technologies for the Pharmaceutical Industry) by Barry Robson, O. K. Baek, SeanEkins Hardcover, 598 Pages, Published 2009 by Wiley ISBN-13: 978-0-470-28953-2, ISBN: 0-470-28953-8
"A unique, integrative look at information-based medicine The convergence of medical science, biology, pharmacology, biomedical engineering, healthcare, and information technology is revolutionizing medical and scientific practice, and has broader social implications still being understood. The Engines of Hippocrates provides a unique, integrative, and holistic look at the new paradigm of information-based medicine, covering a bro ..."
"Raman spectroscopy has advanced in recent years with increasing use both in industry and academia. This is due largely to steady improvements in instrumentation, decreasing cost, and the availability of chemometrics to assist in the analysis of data. Pharmaceutical applications of Raman spectroscopy have developed similarly and this book will focus on those applications. Carefully organized with an emphasis on industry issues, Pharma ..."
"Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics ..."
Pharmaceutical Data Mining(1st Edition) Approaches and Applications for Drug Discovery (Wiley Series on Technologies for the Pharmaceutical Industry) by Konstantin V. Balakin, SeanEkins, Ahmed H.U. Hardcover, 565 Pages, Published 2009 by Wiley ISBN-13: 978-0-470-19608-3, ISBN: 0-470-19608-4
"Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, wh ..."
Computational Toxicology Risk Assessment for Chemicals by SeanEkins 432 Pages, Published 2018 by John Wiley & Sons ISBN-13: 978-1-119-28258-7, ISBN: 1-119-28258-6
"27 Guy, R.H. and Hadgraft, J. (1989). Selection of drug candidates for
transdermal drug delivery, in Transdermal Drug Delivery (eds J. Hadgraft and
R.H. Guy), Marcel Dekker, New York, pp. ... 29 Karande, P., Jain, A., Ergun, K. et
al. (2005) ..."
"Covering a neglected but important topic of management and information technology collaborations in drug discovery and development, this book discusses the state–of–the–art collaborative and computing techniques for the pharmaceutical industry. Tackling problems thoroughly, from both the human collaborative and the data and informatics side, this volume is relevant to the day–to–day activities of running a laboratory or a collaborative ..."
Computational Toxicology(1st Edition) Risk Assessment for Pharmaceutical and Environmental Chemicals (Wiley Series on Technologies for the Pharmaceutical Industry) by SeanEkins Hardcover, 830 Pages, Published 2007 by Wiley-Interscience ISBN-13: 978-0-470-04962-4, ISBN: 0-470-04962-6
"A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) mo ..."
Computational Toxicology Risk Assessment for Chemicals by SeanEkins 432 Pages, Published 2018 by John Wiley & Sons ISBN-13: 978-1-119-28257-0, ISBN: 1-119-28257-8
"Sean Ekins, Series Editor Computational Toxicology: Risk Assessment for
Pharmaceutical and Environmental Chemicals Edited by Sean Ekins
Pharmaceutical Applications of Raman Spectroscopy Edited by Slobodan Sašić
Pathway Analysis for Drug Discovery: Computational Infrastructure and
Applications Edited by Anton Yuryev Drug Efficacy, Safety, and Biologics
Discovery: Enmerging Technologies and Tools Edited by Sean Ekins and Jinghai
J. ..."
"In a provocative look at the pharmaceutical industry, this book breaks through current biases to bring all opinions together and allow readers to form their own vision and strategies for the future."
"High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for fu ..."
"Industry. Sean Ekins, Series Editor Editorial Advisory Board Dr. Renee Arnold (
ACT LLC, USA); Dr. David D. Christ (SNC Partners LLC, USA); Dr. Michael J.
Curtis (Rayne Institute, St Thomas' Hospital, UK); Dr. James H. Harwood (Pfizer,
USA); Dr. Dale Johnson (Erniliern, USA); Dr. Mark Murcko, (Vertex, USA); Dr.
Peter W. Swaan (University of Maryland, USA); Dr. David Wild (Indiana University
, USA); Prof. William Welsh (Robert Wood Jo ..."
"Figure 6.2 AGPI for longitudinal integration of health records . Name. Fuzzy
search is required because of potential variances, such as Robert A. Smith, Bob
Smith, Robert Ashley Smith, Rob Smith, Robert A. Smith Jr., and Robert A Smith
III.Also last names of females change upon marriage. . Date of birth. . Gender. .
Race. The statutory laws in some countries prohibit collecting this information,
although this information is commonl ..."
"Aish, R. (2004) Extensible computational design tools for exploratory architecture
. In: Architecture in the Digital Age: Design and Manufacturing (ed. Branko
Kolarvic). New York, Taylor & Francis Group, pp. 243–252. Franken, B. (2004)
Take-off-spatial install`ation in Terminal II at Munich Airport. In: Diversifying
Digital Architecture (ed. Yu-tung Liu). Basel, Birkh ̈auser, pp. 84–88. Manjubala,
I. (2005) Biomimetic mineral–organi ..."