"This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug ..."
Methods in Molecular Biology Ser.(Reprint) PCR Primer Design 402 by AntonYuryev Paperback, 432 Pages, Published 2010 by Humana Press ISBN-13: 978-1-61737-743-3, ISBN: 1-61737-743-0
"At the heart of most high-throughput methods is the technique of polymerase chain reaction (PCR). This book focuses on primer design, which is critical to both the efficiency and the accuracy of the PCR. With intricate descriptions of basic approaches as well as specialized methods, "PCR Primer Design" is an exceptional reference for all those involved in studying the genome."
"Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void in the literature on illustrated reviews of well-documented and understood mechanisms of human diseases on both cellular and molecular levels. It is built from the powerful knowledgebase of biological relationships with analytical and visualization tools from Pathway Studio™, Elsevier’s proprietary commercial software that harnesses text mining tec ..."
PCR Primer Design (Methods in Molecular Biology) by AntonYuryev Hardcover, 432 Pages, Published 2007 by Humana Press ISBN-13: 978-1-58829-725-9, ISBN: 1-58829-725-X
"At the heart of most high-throughput methods is the technique of polymerase chain reaction (PCR). This book focuses on primer design, which is critical to both the efficiency and the accuracy of the PCR. With intricate descriptions of basic approaches as well as specialized methods, "PCR Primer Design" is an exceptional reference for all those involved in studying the genome."
"Most findings about molecular interactions and cellular regulatory events are published in peer-reviewed scientific literature in the form of scientific jargon. The computerized text-mining algorithms are used to convert free grammar of human language into a set of formalized relationships between biological concepts in order to use this wealth of information. The compendium of such interactions extracted from an entire set of biomedica ..."
"Early estimates indicate that the addition of Chemistry-Cheminformaticsrelated
content can further increase the impact of standalone Pathway Analysis Tools. It
is estimated that an additional 10% savings across different phases of discovery
can be achieved by the inclusion of such content. In addition, Cheminformatics
content have a standalone utility with the Computational Chemistry groups within
the industry and academia. This co ..."
"... P. Nesterova, Anton Yuryev, Eugene A. Klimov, Maria Zharkova, Maria Shkrob,
Natalia V. Ivanikova, Sergey Sozin, Vladimir Sobolev ... Eriksen, K.W., Woetmann
, A., Skov, L., Krejsgaard, T., Bovin, L.F., Hansen, M.L., Grønbaek, K., Billestrup, N
., Nissen, M.H., Geisler, C., ... and Sp1 but repressed by growth factor
independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic
keratinocytes."
"With assistance of Pathway Studio software (Ariadne Genomics Inc., USA) we
have created overview pathway showing principal signaling cascades disturbed
during prostate cancer development and progression. We further discuss the role
of androgen receptor in homeostasis of prostate normal cells and in deregulating
signaling of cancer cells. Due to AR involvement not only in proliferation, but also
in apoptosis, invasive growth and in ..."
PCR Primer Design Vol. 402 by AntonYuryev 431 Pages, Published 2007 by Springer Science & Business Media ISBN-13: 978-1-59745-528-2, ISBN: 1-59745-528-8
"stated otherwise, we will not allow mismatches. We are now ready to define
several problem variants. Problem 1 DPD: Given a set of n strings and integers k,
d, and m, is there a primer of length k and degeneracy at most d that matches at
least m input strings? We defined DPD as a decision problem rather than an
optimization problem. Ideally, one wishes to optimize each of the parameters k m,
and d. As the value of k is usually pred ..."
Pathway Analysis for Drug Discovery Computational Infrastructure and Applications (Wiley Series on Technologies for the Pharmaceutical Industry) by AntonYuryev 304 Pages, Published 2008 by John Wiley & Sons Inc (E) ISBN-13: 978-0-470-39927-9, ISBN: 0-470-39927-9