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Books by Darren Flower






Bioinformatics for Immunomics
(Immunomics Reviews:)
by Matthew Davies, Shoba Ranganathan, Darren R. Flower
Paperback, 192 Pages, Published 2012 by Springer
ISBN-13: 978-1-4614-2485-7, ISBN: 1-4614-2485-2

"Like many words, the term "immunomics" equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism - be that virus, bacteria, fungus, or parasite - or microbial ..."






Immunoinformatics(Reprint)
Predicting Immunogenicity In Silico (Methods in Molecular Biology)
by Darren R. Flower, Humana Press
Paperback, 438 Pages, Published 2010 by Humana Press
ISBN-13: 978-1-61737-725-9, ISBN: 1-61737-725-2

"This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume."






In Silico Immunology(Reprint)
by Jon Timmis, Darren R. Flower
Paperback, 451 Pages, Published 2009 by Springer
ISBN-13: 978-1-4419-4264-7, ISBN: 1-4419-4264-5

"This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care."






Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
(Immunomics Reviews:)
by Darren R. Flower, Yvonne Perrie, Flower Et.Al
Hardcover, 314 Pages, Published 2012 by Springer
ISBN-13: 978-1-4614-5069-6, ISBN: 1-4614-5069-1

"This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathoge ..."






Bioinformatics for Vaccinology(1st Edition)
by Darren R. Flower
Paperback, 312 Pages, Published 2008 by Wiley
ISBN-13: 978-0-470-02711-0, ISBN: 0-470-02711-8

"“… this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it read ..."






Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
(Immunomics Reviews:)
by Darren R. Flower, Yvonne Perrie
Paperback, 314 Pages, Published 2015 by Springer
ISBN-13: 978-1-4899-9795-1, ISBN: 1-4899-9795-4

"This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathoge ..."






Immunoinformatics
Predicting Immunogenicity In Silico (Methods in Molecular Biology)
by Darren R. Flower
Hardcover, 438 Pages, Published 2007 by Humana Press
ISBN-13: 978-1-58829-699-3, ISBN: 1-58829-699-7

"This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume."






In Silico Immunology
by Darren R. Flower, Jon Timmis
Hardcover, 451 Pages, Published 2006 by Springer
ISBN-13: 978-0-387-39238-7, ISBN: 0-387-39238-6

"This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care."






Drug Design(1st Edition)
Cutting Edge Approaches
by Darren R. Flower
Hardcover, 202 Pages, Published 2002 by Royal Society Of Chemistry
ISBN-13: 978-0-85404-816-8, ISBN: 0-85404-816-2

"Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use ..."






Bioinformatics for Vaccinology
by Darren R. Flower
312 Pages, Published 2008 by John Wiley & Sons
ISBN-13: 978-0-470-69982-9, ISBN: 0-470-69982-5

"Pierre Bayle's Dictionnaire Historique et Critique (1696), the Encyclope'die (1751 —1772) of Jean le Rond d'Alembert (1717—1783) and Denis Diderot (1713— 1784) and Smellie's Encyclopaedia Britannica (1768—1771) are perhaps the three best known. Biological databases, immunological or otherwise, are only starting their journeys to completeness. As we shall see below, they need to be expanded and integrated. Many projects are attempting ..."






Bioinformatics for Immunomics
(Immunomics Reviews:)
by Matthew N. Davies, Shoba Ranganathan, Darren R. Flower
Hardcover, 192 Pages, Published 2009 by Springer
ISBN-13: 978-1-4419-0539-0, ISBN: 1-4419-0539-1

"Like many words, the term "immunomics" equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism - be that virus, bacteria, fungus, or parasite - or microbial ..."






Immunomics Reviews Ser.
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines 5
by Darren R. Flower, Yvonne Perrie
314 Pages, Published 2012 by Springer Science & Business Media
ISBN-13: 978-1-4614-5070-2, ISBN: 1-4614-5070-5

"Darren R. Flower, Yvonne Perrie. 4. 10. 11. 12. 13. 14. 15. 16. 17. 19. 20. 21. 22. Scarselli M, Arico` B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, ... Cell Microbiol 8(11):1707–1719 Dobrindt U, Hochhut B, Hentschel U, Hacker J (2004) Genomic islands in pathogenic and environmental microorganisms. Nat Rev Microbiol 2(5):414–424 Hacker J, Blum‐Oehler G, Mu ̈hldorfer I, Tscha ̈pe H (1997) Pathog ..."






Special Publications
Drug Design : Cutting Edge Approaches
by Darren R. Flower
202 Pages, Published 2007 by Royal Society Of Chemistry
ISBN-13: 978-1-84755-070-5, ISBN: 1-84755-070-3

"J. D'Amaro, J.G. Houbiers, J.W. Drijfhout, R.M. Brandt, R. Schipper, J.N. Bavinck, C.J. Melief and Kast, A computer program for predicting possible cytotoxic T lymphocyte epitopes based on HLA class I peptide-binding motifs, Hum. Immunol ., 1995, 43, 13—18. 31. F. Sinigaglia and J. Hammer, Motifs and supermotifs for MHC class II binding peptides, Sette A. Exp. Med., 1995, 181,449—451. 32. C. Zhang, J.L. Cornette, J.A. Berzofsky and ..."






Immunoinformatics
Predicting Immunogenicity in Silico
by Darren R. Flower
438 Pages, Published 2007 by Springer Science & Business Media
ISBN-13: 978-1-60327-118-9, ISBN: 1-60327-118-X

"Marsh, S. G. E., Bodmer, J. G., Albert, E. D., Bodmer, W. F., Bontrop, R. E., Dupont , B., Erlich, H. A., Hansen, J. A., Mach, B., Mayr, W. R., Parham, P., Petersdorf, E. W., Sasazuki, T., Schreuder, G. M. Th., Strominger, J. L., Svejgaard, A., and Terasaki, P. I. (2001) Tissue Antigens 57, 236–83. 6. Orr, H. T., Lopez de Castro, J. A., Lancet, D., and Strominger, J. L. (1979) Biochemistry 18, 5711–20. 7. Lee, J. S., Trowsdale, J., ..."






Drug Design Strategies(1st Edition)
Quantitative Approaches (RSC Drug Discovery)
by David J. Livingstone, Andrew M. Davis, Paolo Gramatica, David E. Thurston, Yvonne Martin, Paul Leeson, Richard A. Lewis, Alexander A. Alex, Sir John Barnard, Dave Leahy, Dermot Mcginnity, Darren Green, Keith James, Darren Flower, Sean Ekins, Albert J. Leo, Dr Tony Long, Gregory L. Warren, Tony Long, John Barnard, Albert Leo, Andy Davis, Rsc Publishing
Hardcover, 516 Pages, Published 2011 by Royal Society Of Chemistry
ISBN-13: 978-1-84973-166-9, ISBN: 1-84973-166-7

"This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative f ..."






Clem & Tang - Not Peeling So Well
by Flowers, Darren
Softcover, Published 2020 by R R Bowker Llc
ISBN-13: 978-1-73494-350-4, ISBN: 1-73494-350-5






In Silico Immunology
by Darren Flower
Ebook
ISBN-13: , ISBN: 






Understanding the Universe
by Darren R. Flower
Published 2000
ISBN-13: 978-0-697-24195-5, ISBN: 0-697-24195-5






Bioinformatics for Vaccinology
by Darren R. Flower
Other Digital
ISBN-13: 978-0-470-69983-6, ISBN: 0-470-69983-3






Lipocalins(1st Edition)
(Molecular Biology Intelligence Unit)
by Bo Åkerström , Darren R. Flower , Niels Borregaard , Jean-Philippe Salier
Hardcover, 204 Pages, Published 2006 by Crc Press
ISBN-13: 978-1-58706-297-1, ISBN: 1-58706-297-6



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