"Like many words, the term "immunomics" equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism - be that virus, bacteria, fungus, or parasite - or microbial ..."
Immunoinformatics(Reprint) Predicting Immunogenicity In Silico (Methods in Molecular Biology) by DarrenR. Flower, Humana Press Paperback, 438 Pages, Published 2010 by Humana Press ISBN-13: 978-1-61737-725-9, ISBN: 1-61737-725-2
"This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume."
"This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care."
"This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathoge ..."
"“… this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it read ..."
"This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathoge ..."
Immunoinformatics Predicting Immunogenicity In Silico (Methods in Molecular Biology) by DarrenR. Flower Hardcover, 438 Pages, Published 2007 by Humana Press ISBN-13: 978-1-58829-699-3, ISBN: 1-58829-699-7
"This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume."
"This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care."
Drug Design(1st Edition) Cutting Edge Approaches by DarrenR. Flower Hardcover, 202 Pages, Published 2002 by Royal Society Of Chemistry ISBN-13: 978-0-85404-816-8, ISBN: 0-85404-816-2
"Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use ..."
"Pierre Bayle's Dictionnaire Historique et Critique (1696), the Encyclope'die (1751
—1772) of Jean le Rond d'Alembert (1717—1783) and Denis Diderot (1713—
1784) and Smellie's Encyclopaedia Britannica (1768—1771) are perhaps the
three best known. Biological databases, immunological or otherwise, are only
starting their journeys to completeness. As we shall see below, they need to be
expanded and integrated. Many projects are attempting ..."
"Like many words, the term "immunomics" equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism - be that virus, bacteria, fungus, or parasite - or microbial ..."
Immunomics Reviews Ser. Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines 5 by DarrenR. Flower, Yvonne Perrie 314 Pages, Published 2012 by Springer Science & Business Media ISBN-13: 978-1-4614-5070-2, ISBN: 1-4614-5070-5
"Darren R. Flower, Yvonne Perrie. 4. 10. 11. 12. 13. 14. 15. 16. 17. 19. 20. 21. 22.
Scarselli M, Arico` B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D,
Ciucchi L, Cartocci E, ... Cell Microbiol 8(11):1707–1719 Dobrindt U, Hochhut B,
Hentschel U, Hacker J (2004) Genomic islands in pathogenic and environmental
microorganisms. Nat Rev Microbiol 2(5):414–424 Hacker J, Blum‐Oehler G, Mu
̈hldorfer I, Tscha ̈pe H (1997) Pathog ..."
Special Publications Drug Design : Cutting Edge Approaches by DarrenR. Flower 202 Pages, Published 2007 by Royal Society Of Chemistry ISBN-13: 978-1-84755-070-5, ISBN: 1-84755-070-3
"J. D'Amaro, J.G. Houbiers, J.W. Drijfhout, R.M. Brandt, R. Schipper, J.N. Bavinck,
C.J. Melief and Kast, A computer program for predicting possible cytotoxic T
lymphocyte epitopes based on HLA class I peptide-binding motifs, Hum. Immunol
., 1995, 43, 13—18. 31. F. Sinigaglia and J. Hammer, Motifs and supermotifs for
MHC class II binding peptides, Sette A. Exp. Med., 1995, 181,449—451. 32. C.
Zhang, J.L. Cornette, J.A. Berzofsky and ..."
Immunoinformatics Predicting Immunogenicity in Silico by DarrenR. Flower 438 Pages, Published 2007 by Springer Science & Business Media ISBN-13: 978-1-60327-118-9, ISBN: 1-60327-118-X
"Marsh, S. G. E., Bodmer, J. G., Albert, E. D., Bodmer, W. F., Bontrop, R. E., Dupont
, B., Erlich, H. A., Hansen, J. A., Mach, B., Mayr, W. R., Parham, P., Petersdorf,
E. W., Sasazuki, T., Schreuder, G. M. Th., Strominger, J. L., Svejgaard, A., and
Terasaki, P. I. (2001) Tissue Antigens 57, 236–83. 6. Orr, H. T., Lopez de Castro,
J. A., Lancet, D., and Strominger, J. L. (1979) Biochemistry 18, 5711–20. 7. Lee,
J. S., Trowsdale, J., ..."
"This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative f ..."